Biological Adhesive Drug Delivery System - Basic Principles, New Methods, and Recent Advances

Author: Ma Xiwiziqi Leirsun Zhijie
Publisher:
Publish Date: 2003-01-01
Features: About this book: This important reference book comprehensively reviews fundamental methods for characterizing bioadhesive materials and improving drug-absorbing carriers, enabling the preparation of novel drug formulations using existing compounds at lower R&D costs through recombination. The book is authored by over 50 internationally renowned experts, reflecting broad knowledge—both traditional bioadhesive techniques and novel clinical applications. It discusses mechanics and chemical bonding, polymer-mucilage interactions, the influence of surface energy on bioadhesion, polymer hydration, and mucilage rheology. It analyzes the physicochemical properties of mucilage and glycoproteins, cell adhesion molecules, and the interaction between cells and two-dimensional and three-dimensional surfaces. It covers methods such as microbalances, magnetic sensors, atomic force microscopy, direct measurement of molecular-level adhesion, and measurement of intercellular interactions. It examines bioadhesive carriers, diffusion or penetration enhancers, and exogenous lectin carriers, describes vaginal, nasal, oral, ocular, and transdermal drug delivery systems, reviews the interaction of bioadhesives with ocular, oral, and mucosal tissues in the respiratory, urinary, and gastrointestinal systems, and explores issues in product development, clinical testing, and production, among other topics. About the authors: EDITH MATHIOWITZ, Professor of Medical and Engineering at Brown University in Providence, Rhode Island, and supervisor of graduate courses in artificial organs, biomaterials, and cellular technology. She has developed over 150 journal articles, abstracts, and briefs as author or co-author. DONALD E. CHICKERING III, Manager of Formulation and Processing Research at Acusphere Company in Cambridge, Massachusetts. He has published over 25 journal articles, abstracts, and briefs on drug technology as author or co-author and holds four patents. He was the former project manager of Sulzer Carbomedics drug delivery systems in Austin, Texas. He is a recipient of the American Association for the Advancement of Medical Instrumentation's Young Investigator Award. CLAUS-MICHAELLEHR, Director of the Department of Biopharmaceutics and Pharmaceutical Technology at Saarland University in Saarbrücken, Germany. He has published over 40 journal articles, reviews, and book chapters as author or co-author and holds three patents. The content of this book is divided into four parts: Basic Principles of Bioadhesion; Evaluation Methods for Bioadhesive Interactions; New Concepts and Strategies for Designing Bioadhesive Drug Delivery Systems; Issues in Bioadhesive Drug Delivery System Development: Products and Clinical Trials. This book introduces various aspects of bioadhesion technology and related perspectives, including the development of new bio-controlled release systems. It begins with fundamental theories and also presents some well-known examples. The central issue of this book is to explore the basic mechanisms of bioadhesion and how to develop bio-carriers for drug release based on this foundation. This book is suitable for engineering and technical personnel engaged in adhesive research and development, as well as professionals in the biomedical field. It also holds significant reference value for teachers, graduate students, and undergraduates in related disciplines.