Is the possibility of genetic inheritance across generations high in cases of close-kin marriage?

Patient's question:

Hello, I have a question to ask. My in-laws are first cousins who got married, which is considered consanguineous marriage. All three of my husband's sisters are normal, but I'm worried about whether our child might have certain genetic diseases. How can we prevent this? Is there a high risk of genetic inheritance across generations?

Doctor's answer:

As you mentioned this situation, generally speaking, the possibility of hereditary transmission is relatively rare. In the case you described, both conditions should be considered problematic, as they are both genetic diseases. Therefore, if both conditions test positive, further diagnosis should be conducted, and in necessary cases, pregnancy should be terminated.

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