Does Trisomy 21 syndrome only occur in girls?

Patient's question:

Hello, may I ask if the first child is fine, and the second child has Down syndrome? Hello, may I ask if the first child is fine, and the second child has Down syndrome? I heard from the doctor that if the girl has the syndrome, the next child, if it's a girl, will also have the syndrome, unless it's a boy. Is that correct?

Doctor's answer:

According to your description, the first child is fine, and the second child has a possibility of having Down syndrome. If the girl has Down syndrome, and if she gives birth to a girl, it is also possible that the child could have Down syndrome. Down syndrome is not related to the gender of the child; it only involves the probability of inheritance and has no relation to gender.

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