What could be the reason for not having a menstrual period for 51 days?

Patient's question:

Detailed medical condition and consultation purpose: My girlfriend's menstrual cycle is not very regular. It has been 51 days since her last period. There have been a few instances of ML (presumably referring to sexual activity) in between, but she always used protection. My girlfriend also took a pregnancy test, which was negative. What could be the reason for this? Her menstrual cycles over the past three months were (in reverse order) 39 days, 33 days, and 25 days.
Additional information: (Her cycle was 39 days last month, 33 days the month before, and 25 days before that. She has been very irregular in the past, and during this period, she only had sex three times. Each time, she used a condom, which she is certain did not leak, as she checked it afterward. However, I have a habit of...

Doctor's answer:

Hello, it's the safe period, so the possibility of pregnancy is not high. However, the safe period is not 100% safe and there is still a possibility of an unexpected pregnancy. If you have had sexual activity and your period is delayed by more than 7 days, you should first take a pregnancy test. Once it is confirmed that you are not pregnant, you should also check for any gynecological inflammation. Additionally, factors such as fatigue, poor rest, stress and anxiety, environmental changes, gynecological inflammation, and endocrine disorders can all lead to a delayed period. If you are not pregnant but your period still hasn't arrived, it is recommended to visit a gynecological department in the hospital for examination to identify the cause before treatment.

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