Patient's question:
My girlfriend is very afraid of pain. She doesn't dare to get a tire fixed. But we can't have the child right now either. We haven't confirmed if we are pregnant yet? But we need to be prepared earlier. If we are pregnant, what medicine can be used to terminate the pregnancy directly without causing much pain?Doctor's answer:
Hello: Currently, the only painless abortion method is the painless abortion. Any other form of abortion will cause some degree of pain. However, medication abortion also requires actively going to the hospital for a detailed examination. After the family members sign, the medication can be obtained.Mechanism of Action of Medication Abortion:
Mifepristone: Its main function is as an antiprogesterone.
(1) As a progesterone antagonist, it can replace natural progesterone in acting on the endometrium, occupying the progesterone receptors on endometrial cells.
(2) Its antiprogesterone effect leads to necrosis of the decidua, detachment and bleeding, dissolution of the corpus luteum, and stimulation of endogenous prostaglandin production.
(3) It acts on the hypothalamus and pituitary, inhibiting the secretion of gonadotropins, which also leads to corpus luteum dissolution.
(4) It promotes the degradation of cervical collagen fibers, softening the cervix.
(5) It enhances the sensitivity of uterine muscles to prostaglandins.
Prostaglandins: Commonly used include carboprost and misoprostol. Their mechanisms of action are as follows:
(1) They cause contractions of the uterine smooth muscle.
(2) After uterine contractions, intrauterine pressure increases, leading to vasoconstriction of chorionic villi, local hypoxia, and necrosis and degeneration of decidua tissue, thereby disrupting the mechanisms that maintain early pregnancy.
(3) The synthesis of cervical collagen fibers is inhibited, making the cervix soft and easy to dilate.
(4) In animals, it has been observed to dissolve the corpus luteum.
When these two drugs are used in combination, they achieve anti-implantation, cervical softening, and uterine contractions to induce abortion. This makes medication abortion a simple, safe, effective, low-side-effect, and low-pain method.
Indications:
1) Abnormal