Etiology of nonliquefaction of semen

Patient's question:

Ejaculate does not liquefy, what are the reasons causing it? Hello, after being married for two years without using any contraception, I haven't had a child. Later, I went to the hospital for a check-up and was told that my semen does not liquefy. I would like to ask, what are the reasons that cause semen not to liquefy?

Doctor's answer:

Hello: The coagulation of semen is caused by coagulation protein produced by the seminal vesicles. On the other hand, liquefaction is the result of a series of proteolytic enzymes secreted by the prostate, known as liquefaction factors. Therefore, when the prostate and seminal vesicles become inflamed, their secretion function is disrupted, leading to an increase in coagulation factors or a decrease in liquefaction factors, which results in semen not liquefying. Unliquefied semen causes sperm to be trapped in a mucous network, hindering their motility in the female reproductive tract, thus leading to male infertility.

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