What are the reasons for semen not liquefying?

Patient's question:

Hello doctor, I would like to ask what are the causes of sperm liquefaction failure? I have developed a condition of semen liquefaction failure, and I don't know how I got this disease. We really want to have a child, but we can't get pregnant. Is this related to the cause? How should I be treated? What are the causes of sperm liquefaction failure?

Doctor's answer:

Hello: The coagulation of semen is caused by coagulation proteins produced by the seminal vesicles. On the other hand, liquefaction is the result of a series of proteolytic enzymes secreted by the prostate, known as liquefying factors. Therefore, if the prostate and seminal vesicles become inflamed, their secretion function may be disrupted, leading to an increase in coagulation factors or a decrease in liquefying factors, which can cause semen to fail to liquefy. Unliquefied semen causes sperm to be trapped in a mucous network, hindering their motility in the female reproductive tract, thus leading to male infertility.
Advice: Treatment must be targeted and tailored to each individual's specific condition and underlying cause to achieve faster results. It is recommended that you visit a reputable and professional "technologically advanced" infertility specialist hospital to undergo a targeted examination based on your personal circumstances. Under the guidance of a doctor, receive symptomatic treatment to improve your health. Good luck!

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