What factors can cause semen to fail to liquefy

Patient's question:

Hello doctor, I would like to consult about the factors that can cause semen to fail to liquefy. My friend got married a year later than me, but now their child is already 2 years old, and we haven't been able to conceive yet. Yesterday, the doctor said it was an issue with my husband's semen not liquefying. Will this have a significant impact on fertility? What are the reasons that can cause semen to fail to liquefy?

Doctor's answer:

Hello,
1. Mycoplasma, Chlamydia trachomatis, and Neisseria gonorrhoeae infection: If a patient is infected with mycoplasma, it can lead to dysfunction of the accessory glands, causing changes in semen composition directly, resulting in semen nonliquefaction and thus affecting fertility.
2. Prostatitis: Prostatitis can cause semen nonliquefaction in patients. Experts explain that the liquefaction and coagulation of semen are regulated by coagulating proteins and liquefying factors in the semen. As enzymes that act as liquefying factors, when prostate secretion activity decreases, their activity weakens continuously, leading to semen nonliquefaction in patients.
3. Idiopathic nonliquefaction: Some patients with semen nonliquefaction may also have idiopathic nonliquefaction, which has very poor outcomes in clinical treatment.
Advice: What factors can cause semen nonliquefaction?
Since each person's condition and symptoms are different, identifying the root cause is essential for targeted treatment. It is recommended that you go to the Fast Pregnancy Expressway designated hospital to clarify the specific cause and receive targeted treatment. Do not miss the best time for treatment.
Wishing you health!

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