Phenotypic Genetic Modification and Tumors

Author: Fang Jingyuan
Publisher:
Publish Date: 2003-04-01
Features: In the regulation of gene expression, phenotypic genetic modification (epigenesis, also translated as epigenetic modification, extragenetic modification, or postnatal modification) plays a dominant role. Chromosomes are composed of DNA and histones. The main content of the theory of phenotypic genetic modification is the methylation of DNA that downregulates transcription, while the closely related histone acetylation, which enhances gene expression, is often discussed together. Many diseases, such as certain genetic disorders, viral infections, and tumors, are affected by phenotypic genetic changes. During the occurrence of various tumors, there is hypomethylation of oncogenes and hypermethylation of tumor suppressor genes, as well as disruptions in acetylation. By intervening in the abnormal phenotypic genetic modifications mentioned above, the progression of tumors can be influenced. This book is a specialized work on the theory of phenotypic genetic modification in China, referencing research literature from recent years abroad, and systematically elaborates on the relevant concepts of phenotypic genetic modification, changes in phenotypic genetic modification during tumor occurrence, and the various factors influencing these changes. It holds certain theoretical significance and clinical guiding value for further enriching the content of the theory of phenotypic genetic modification and conducting in-depth research on its impact on the occurrence and development of diseases such as tumors. This book is suitable for reference and application by graduate students, laboratory personnel, and clinical workers in the fields of genetics, molecular biology, and oncology.