Optimization of Organic Synthesis Processes

Author: Chen Rongye
Publisher:
Publish Date: 2006-01-01
Features: This book studies reaction selectivity using kinetic methods, transforming fundamental concepts of chemical kinetics into practical organic synthesis techniques. The book is divided into 19 chapters. Chapters 1 and 2 introduce the theoretical aspects of studying reaction processes and simple, practical separation techniques using kinetic methods. Chapters 3 to 17 provide detailed applications, covering topics such as the nitration of aromatic hydrocarbons with mixed acids, sulfonation of aromatic hydrocarbons, alkylation and acylation of aromatic hydrocarbons, halogenation of aromatic rings, synthesis of aromatic ethers, amination of halogenated aromatic hydrocarbons, nitrile formation from halogenated hydrocarbons, diazohydrogen hydrolysis of aromatic hydrocarbons, free radical substitution of diazonium groups, process conditions for diazonium halogenation reactions, synthesis of fluorinated aromatic hydrocarbons, halogenation of aromatic hydrocarbon side chains, preparation and reactions of Grignard reagents, addition and condensation of carbonyl groups, and heterocyclic compounds. Chapters 18 and 19 discuss the comparison of reagent activity and industrial scaling of organic synthesis reactions. The book is highly theoretical, well-structured, and suitable for professional researchers and developers in organic synthesis, training instructors, and graduate students.