Patient's question:
Description of the problem: Anti-sperm antibodies and anti-endometrial antibodies are both positive. Will this affect pregnancy? How should it be treated? Thank you!Doctor's answer:
Hello: Affects fertility, this condition belongs to immunological infertility, and all of them need treatment. Antisperm antibodies are a complex pathological product, which can affect both men and women. The exact factors or causes have not been fully clarified. The sperm and seminal fluid of men are specific antigens for women. Upon contact with blood, they can cause immune reactions in both men and women, leading to the production of corresponding antibodies that hinder the combination of sperm and eggs, resulting in infertility. The above conditions belong to sperm immunological infertility. Female patients with positive antisperm antibodies often have reproductive system inflammation such as endometritis, vaginitis, and tubulitis before the onset of the disease. This is particularly common in cases of tubal blockage infertility. These patients often have a history of sexual intercourse during menstruation, postpartum lochia, or abnormal vaginal bleeding. Even if they have the opportunity to conceive, the fertilized egg may be affected by the disease or weakened due to exhaustion, making it highly prone to atrophy or death during the embryonic stage, leading to spontaneous abortion. In men, about 10% of infertile individuals have positive antisperm antibodies in their blood. Under normal circumstances, the testes and male reproductive tract have a strong immune barrier, preventing sperm from contacting the immune system of the body, thus rarely causing immune reactions. This condition is also caused by diseases. For example, inflammation of the male reproductive tract or other factors or causes that block the vas deferens may lead to the leakage of sperm, or the vas deferens may be ligated and cut off, blocking the passage of sperm. This can cause the sperm antigen to come into contact with the body's immune system, leading to the production of antisperm antibodies. As a result, sperm clumping, immobilization, and loss of normal vitality make it difficult to complete the combination with the egg. Our hospital adopts isolation therapy and immunosuppressive therapy for immunological infertility. We recommend that you come to our hospital for early treatment and do not miss the best age for conception.