What are the interference factors for pregnant women of advanced age?

Patient's question:

Detailed medical condition and consultation purpose: Interfering factors in pregnancy for elderly women

Doctor's answer:

Hello: The term "late marriage and late childbirth women" typically refers to women aged 23 and above who are of childbearing age, while "advanced maternal age women" refers to women aged 35 and above. At this age, the incidence of children with mental retardation and congenital deformities significantly increases, and excessive maternal age can also lead to dystocia and an increased fetal mortality rate.
Because of advanced maternal age, oocytes may undergo changes. The human body, including the ovaries, is exposed to more various types of radiation and harmful substances, which increase the likelihood of genetic mutations. Chromosomal non-disjunction during cell division is common, most notably the failure of chromosome 21 to separate, resulting in congenital Down syndrome. Chromosomal analysis of affected children reveals three copies of chromosome 21, hence the alternative name "trisomy 21 syndrome." Individuals with this condition exhibit severe intellectual disability and are unable to live independently as adults. In addition to external abnormalities, they may also have internal organ deformities such as heart and digestive system issues. Recent studies have also found that very young mothers or fathers over the age of 55 may also be affected.
Therefore, any woman aged 35 or above who has given birth to a child with congenital Down syndrome, or who has a family history of the condition, should consult a clinic for necessary examinations. Additionally, prenatal diagnosis should be conducted during subsequent pregnancies to determine if there is a risk of trisomy 21 syndrome. If the fetus has a normal chromosome count, the pregnancy can continue until delivery. However, if chromosomal abnormalities are detected, the pregnancy should be terminated early.
Pre- and post-pregnancy precautions for women of advanced maternal age:
First, for women who wish to conceive at an advanced age, prenatal conditioning is a crucial aspect of preparation.