Menstruation hasn't come for half a month and I'm not pregnant, what could be the reason?

Patient's question:

My wife hasn't had her period for half a month. After using a pregnancy test, it showed she wasn't pregnant.

Doctor's answer:

The menstrual cycle of women is regulated by the hypothalamic-pituitary-ovarian axis. Except during pregnancy, various factors such as mental stress, emotional fluctuations, and environmental changes; local inflammation, tumors, or developmental abnormalities of the reproductive organs; malnutrition, intracranial disorders, and other endocrine dysfunctions; medications; and nutritional status can all disrupt the function of this axis, leading to menstrual irregularities. It is recommended to visit a hospital for tests including the six major sex hormones and an ultrasound to identify the underlying cause and receive targeted treatment.

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