Patient's question:
Antiphospholipid antibody IgG weak positive, IgM negative. Currently pregnant, will I have a miscarriage? Previously, the antiphospholipid antibody was positive, and after taking a bottle of aspirin, it turned weakly positive. I had two miscarriages before. One was at 50 days without a heartbeat, but the gestational sac was still growing, and the doctor recommended a miscarriage. Now I'm really worried.Doctor's answer:
Hello! Pregnancy complicated with antiphospholipid syndrome (APS) often causes pregnancy loss, intrauterine growth restriction (IUGR), preeclampsia, and other complications, and its pathogenesis has been controversial. It is now believed that antiphospholipid antibodies produced in the body induce thrombosis, which is the main factor in placental thrombosis and pregnancy failure. Pregnancy complicated with APS often leads to severe maternal complications, such as preeclampsia, recurrent miscarriage, intrauterine fetal death, preterm birth, and other adverse fetal outcomes. These manifestations are related to the pathological and physiological changes of the placenta. When a patient with APS is pregnant, secondary placental dysplasia and placental insufficiency may occur.Medical advice: The treatment and efficacy of pregnancy complicated with positive antiphospholipid antibodies are related to the pathological histology of the placenta. The main treatment methods currently include antithrombotic therapy, anticoagulation, and immunosuppression. Heparin, aspirin, and prednisone are commonly used in clinical practice, either in combination or in various combinations, but there is no consensus on the optimal regimen.
During the first month of the first trimester of pregnancy, intravenous immunoglobulin is administered for 5 days. Wishing you a smooth pregnancy!