Patient's question:
Irregular menstruation, lower back pain.Doctor's answer:
1. Family genetic factors: Based on the high familial aggregation observed in the occurrence of polycystic ovary syndrome (PCOS), genetic factors are a major etiological component. Most cases of PCOS are associated with genetic abnormalities, while a few involve chromosomal abnormalities. This predisposing factor is difficult to avoid, and early detection and treatment are the only preventive measures.2. Obesity, hyperinsulinemia: Some patients with PCOS, particularly those who are obese, may exhibit hyperinsulinemia and insulin resistance, suggesting that the condition is caused by insulin resistance. The causes of insulin resistance are varied, with most cases resulting from dysfunction in the insulin receptor post-transduction system, while others may be due to insulin receptor defects.
3. Chronic stress, medication, and disease effects: Due to the impact of stress, medication, and certain diseases on the hypothalamic-pituitary-ovarian (HPO) axis regulatory function, abnormal production of androgens by ovarian stroma and follicular theca cells may occur. High androgen levels within the ovaries inhibit follicular maturation, leading to a series of PCOS symptoms such as amenorrhea and hirsutism.
4. Adrenal gland dysfunction: 50% of PCOS patients exhibit abnormal adrenal cortex function, often due to hyperfunction of the adrenal cortex, which leads to excessive androgen secretion and symptoms like anovulation. Diseases that cause adrenal cortex dysfunction primarily include adrenal tumors and adrenal cortex hyperplasia.