Patient's question:
In May 2016, there was a fetal heartbeat, but it later stopped developing, and the cause was unknown. In November 2016, a thorough check revealed negative (blocking antibodies), and due to significant controversy, the pregnancy was not carried forward. In May 2017, there was an empty sac, and the embryo's detailed examination results showed trisomy of chromosome 8. Is it possible that both of my successful pregnancies were triggered by negative blocking antibodies? How is it that they only turn positive after getting pregnant and remain negative otherwise? Do I need treatment?Doctor's answer:
A negative test can lead to miscarriage. In the serum of normal pregnant women, there exists a specific IgG antibody against the lymphocytes of their direct relatives. This antibody can inhibit lymphocyte responses, isolate maternal lymphocytes from the cytotoxic effects on the cultured trophoblast cells, prevent the suppressor of T cell recognition of fetal antigens, and block the mother's immune system from attacking the embryo remotely. It isolates lymphocytes stimulated by allogeneic antigens to produce macrophage rapid movement suppressor factor, hence the name "blocking antibody." In simple terms, in most normal pregnancies, most women have blocking antibodies. If there is a lack of blocking antibodies, and the antibody test shows a negative result, active treatment is required to ensure a smooth delivery.Recommendation: If you want to have children, consider undergoing perinatal IVF.