What causes azoospermia?

Patient's question:

I have been married for many years and still have no children. At first, I thought it was my wife's problem, but after both of us went to the Provincial People's Hospital for check-ups, we found that it was my issue. I have azoospermia, and I have been taking medication for treatment without achieving the desired results. I don't know if my condition can be cured.

Doctor's answer:

Azoospermia is a type of abnormal sperm and seminal fluid, and it is one of the factors or causes of male infertility. Azoospermia can be divided into non-obstructive azoospermia and obstructive azoospermia. We will understand the factors or causes of azoospermia from these two aspects:
(1) Factors or causes of non-obstructive azoospermia:
- Genetic diseases: Chromosomal abnormalities in autosomes or sex chromosomes, which affect sperm production in the testes, such as Klinefelter syndrome.
- Testicular lesions: Such as testicular trauma, inflammation, torsion, and testicular vascular diseases.
- Congenital testicular abnormalities: Abnormal testicular development or abnormal testicular position can hinder sperm production.
- Endocrine diseases: Hyperfunction or hypofunction of the pituitary gland, pituitary tumors, hyperfunction or hypofunction of the adrenal glands, hyperthyroidism or hypothyroidism, can all affect sperm production and lead to azoospermia.
- Severe systemic diseases and malnutrition can also cause azoospermia.
(2) Factors or causes of obstructive azoospermia:
- Congenital malformations: Commonly include ectopic head of the epididymis, obstruction of the epididymal duct, absence or underdevelopment of the vas deferens.
- Infections with gonococcus, tuberculosis, and other bacterial infections can cause obstruction of the epididymis and vas deferens.
- Cysts in the epididymis compressing the epididymal duct, leading to obstruction.
- Injuries that block the male reproductive tract.

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