Does dysfunctional uterine bleeding have anything to do with taking progesterone?

Patient's question:

I have been experiencing dysfunctional uterine bleeding for over a month. Then I took progesterone for three days. When I was taking it, the bleeding didn't stop. What could be the situation? If the bleeding stops, how many days will it last? If the bleeding doesn't stop after taking progesterone, will there be a lot of blood flow in two days? Today, suddenly a lot of blood came out with many blood clots, more than usual, and it soaked through my pants. I want to ask if this situation is related to taking progesterone? Is the heavy bleeding a sign of a hemorrhage?

Doctor's answer:

Based on your situation, I speculate that you have had abnormal uterine bleeding for over a month, and taking progesterone for a few days has caused the endometrium to transform into the exfoliative phase. If it's dysfunctional uterine bleeding, taking progesterone usually stops the bleeding within 72 hours. After stopping the medication 4-5 days later, you may experience red bleeding again. This is the effect of progesterone, which causes the complete shedding of the endometrium, leading to red bleeding. It typically takes about a week to clear up and should not exceed ten days. This is also known as pharmacological curettage. However, before using this method, a blood test is required to check for anemia. Hemoglobin must be >80 for it to be appropriate. This is because stopping the medication may lead to heavier red bleeding.

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