Patient's question:
Polycystic ovary syndrome, irregular menstrual cycle, failed pregnancy Polycystic ovary syndrome, irregular menstrual cycle, failed pregnancy, what to doDoctor's answer:
Clomiphene is the first-line medication for PCOS, with an ovulation rate of 60% to 80% and a pregnancy rate of 30% to 50%. Clomiphene competes with endogenous estrogen receptors at the hypothalamic-pituitary level, inhibiting estrogen negative feedback and increasing the pulse frequency of GnRH secretion, thereby adjusting the secretion ratio of LH and FSH. Clomiphene also directly promotes the synthesis and secretion of estrogen by the ovaries. After taking this medication, the ovaries may enlarge due to excessive stimulation (13.6%), vasodilation with hot flashes (10.4%), abdominal discomfort (5.5%), blurred vision (1.5%), or side effects such as rash and mild hair loss.