Patient's question:
NoDoctor's answer:
(1) Gonadotropin-releasing hormone agonists (GnRH-a) are currently commonly used in clinical practice. Common GnRH-a medications include leuprolide (Lupron), goserelin (Zoladex), and triptorelin (Decapeptyl). GnRH-a is not suitable for long-term continuous use and is typically used only for preoperative pretreatment, generally for 3 to 6 months, to avoid severe menopausal symptoms caused by low estrogen levels. It can also be supplemented with a small dose of estrogen to counteract this side effect.(2) Mifepristone is a progesterone antagonist that has been clinically used in recent years to treat uterine fibroids. It can reduce the size of fibroids, but they often grow back after discontinuation of the medication.
(3) Danazol is used for preoperative medication or to treat uterine fibroids that are not suitable for surgery. After discontinuation, uterine fibroids may grow. Taking danazol can cause liver damage, and it may also lead to androgen-induced side effects (such as weight gain, acne, and hoarseness).