Patient's question:
Infertility for three years after marriage. Upon investigation, it was found to be caused by endometrial hyperplasia. The condition has not been cured despite long-term treatment, and she has been taking compounded progesterone. Now, she has no menstruation even without progesterone. She wants to consult whether the endometrial hyperplasia is severe.Doctor's answer:
The primary cause of endometrial hyperplasia is primarily related to long-term estrogen exposure. Simple fibrosis is believed to be a physiological response of the endometrium to the body's high estrogen state. The most common cause is anovulation, which frequently occurs in women during menarche or before menopause. If menopause occurs again or progesterone treatment is used, inflammation can subside and return to normal, generally not progressing to cancer. In cases of cross-linked fibrosis, a very small number can progress to atypical hyperplasia, thereby affecting prognosis. The canceration rate of atypical hyperplasia is 23%, with severe atypical hyperplasia reaching a canceration rate of 30% to 50%, hence it is classified as a precancerous lesion.