Does taking estrogen medication cause the endometrium to thicken?

Patient's question:

I have an itchy lower body, and my underwear is always yellow. What's going on? Does taking estrogen medication cause endometrial hyperplasia?

Doctor's answer:

The endometrium is in a fibrotic state, generally under the effect of estrogen, so taking estrogen may potentially cause the endometrium to be in a fibrotic state. However, after menopause, it is under the effect of estrogen and progesterone that it transitions to the secretory phase, forming the cyclic menstrual cycle. If a careful ultrasound examination reveals that the endometrium is too thin, it is appropriate to take some estrogen to supplement it. Otherwise, under normal circumstances, supplementation is not necessary.

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