Can low progesterone cause miscarriage?

Patient's question:

Last year, when my wife was in the second trimester of pregnancy, her progesterone levels dropped again, leading to a condition of embryonic arrest. Does low progesterone cause fetal demise?

Doctor's answer:

Progestogen levels above 20 require close monitoring. If the levels continue to drop, it's crucial to start supporting the pregnancy immediately, as this is the most dangerous stage. A decline in progestogen indicates poor luteal function.
At 8 weeks, the baby's growth and development must transition from being stimulated by progestogen to being regulated by hormones secreted by the placenta. However, at this stage, the placenta has not yet fully developed, so it cannot take over its role. If the corpus luteum regresses again, it will create another gap, making this period particularly risky. Most natural miscarriages and fetal demise occur during this time. Therefore, extreme caution is necessary. Take medication as prescribed, rest more and avoid excessive movement, and regularly monitor your progestogen levels. If needed, consult your doctor about supporting the pregnancy.

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