Can high 17-hydroxyprogesterone lead to miscarriage?

Patient's question:

How can high progesterone lead to a recurrent miscarriage? What range of progesterone levels is considered high? The recent check-up said my 17-hydroxyprogesterone is too high—will it really cause a miscarriage? What treatment do I need, and what should I pay attention to?

Doctor's answer:

Normal values of 17α-hydroxyprogesterone in women of childbearing age: Follicular phase 0.1~0.8 ng/ml; Luteal phase 0.27~2.9 ng/ml. By the end of the third month of pregnancy 2~12 ng/ml. Male: 0.31~2.13 ng/ml. 17α-hydroxyprogesterone is an endogenous progestogen, which can be produced by the human body itself. Except for chemical preparations.

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