Pharmacokinetics

Author: Wang Guangji
Publisher:
Publish Date: 2005-08-01
Features: Pharmacokinetics is a discipline that quantitatively studies the absorption, distribution, metabolism, and excretion of drugs in the body. In the process of developing innovative drugs, pharmacokinetic research holds the same important position as pharmacodynamic research and toxicological research, and has become an essential part of preclinical and clinical drug research. This book focuses on the theory of pharmacokinetics and its role in new drug research. Compared to similar books, its innovation lies in emphasizing the introduction of modern pharmacokinetic theory and the application of classical pharmacokinetics in the research of new drugs and their formulations, as well as the rapidly developing in vitro models for pharmacokinetic research. The book consists of thirteen chapters, including Overview, Drug Intravenous Transport, Metabolic Studies of Drugs, Classical Compartment Model Theory, Nonlinear Pharmacokinetics, Non-Compartmental Statistical Moment Methods, Bioavailability and Bioequivalence Evaluation of Drug Formulations, Clinical Pharmacokinetics, Pharmacokinetic-Pharmacodynamic Combined Models, Physiologically Based Pharmacokinetic Models and Their Practice, Pharmacokinetics of Chiral Drugs, Preclinical Pharmacokinetic Research of New Drugs, Curve Fitting of Pharmacokinetic Data, and Common Software. The book provides certain examples combined with theoretical explanations. It can be used as a textbook for senior undergraduate and graduate students, as well as a reference for researchers engaged in pharmacokinetic research and related scientific fields. The book focuses on the theory of pharmacokinetics and its role in new drug research. Compared to similar books, its innovation lies in emphasizing the introduction of modern pharmacokinetic theory and the application of classical pharmacokinetics in the research of new drugs and their formulations, as well as the rapidly developing in vitro models for pharmacokinetic research.