Patient's question:
I've been married for several years, and so far, we haven't had any children. I'm very anxious about it and don't know if it's my problem. I've asked my husband to get checked, but he refuses. I'm afraid my condition will worsen. Could you please tell me what are the harms of immunological infertility and what are the dangers of immunological infertility?Doctor's answer:
Hello, the hazards of immunological infertility include the following points: Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm immobilizing antibodies have a cytotoxic response, causing sperm to die or interfering with sperm movement. Additionally, they may also interfere with sperm metabolism and the function of sperm condensing proteins.Interfering with the movement of sperm enzymes, inhibiting the concentration effect of the zona pellucida and the corona radiata, including:
① Acrosin: Can promote sperm penetration through the zona pellucida and enhance fertilization;
② Hyaluronidase: Can cause the cumulus oophorus (corona radiata) to concentrate.
Sperm antibodies mainly inhibit the activity of hyaluronidase, affecting the concentration effect of sperm and interfering with embryonic development and growth.