Patient's question:
What are the causes of immunological infertility? I've been married for several years, but I still don't have any children. I'm very anxious myself, not knowing if it's my problem. I asked my husband to get checked, but he refuses. I'm afraid my condition will worsen. What should I do?Doctor's answer:
Hello: Sperm, seminal plasma, zona pellucida, and ovary are all antigens of the reproductive system that can cause autoimmune or alloimmune reactions, producing additional antibodies that hinder the combination of sperm and eggs, leading to infertility. The following are autoimmune factors:Sperm autoimmune: Sperm have a large number of specifically expressed sperm antigens, which can cause autoimmune reactions in males or alloimmune reactions in females.
Fluid immune abnormalities: Antibodies against the zona pellucida can be produced in the female body, leading to infertility.
Endometrial local cellular autoimmune abnormalities: The endometrium has a large number of autoimmune cells that help with embryo implantation. Abnormal function of these local endometrial cells can result in unsuccessful implantation and infertility.