Patient's question:
What are the causes of immunological infertility? Hello, I want to understand what immunological infertility is. What are the health tips for immunological infertility? I have been married for several years, but I still don't have any children. I am very anxious myself, not knowing if it is my problem. I asked my husband to get checked, but he refuses. I am afraid that my condition will worsen. What is going on?Doctor's answer:
The main reasons for immunological infertility are as follows:1. The Fc segment of antisperm antibodies binding to cervical mucus glycoproteins affects sperm penetration through the cervical mucus during the ovulatory period, leading to female infertility.
Why is immunological infertility caused? Antisperm antibodies generated at the head of sperm impair sperm motility, resulting in female infertility.
The regulatory effect of antisperm antibodies reduces the phagocytosis of sperm by local phagocytes in the reproductive tract.
Cytotoxic antibodies, in the presence of complement, cause damage to the sperm cell membrane, making sperm ( means "near death" or "" in Chinese, which should be translated as "" or "near death"). Antisperm antibodies targeting the tail inhibit sperm movement, leading to immunological infertility again.
Antisperm antibodies at the head of sperm can block the binding of sperm to the zona pellucida and oolemma, preventing fertilization, ultimately resulting in immunological infertility.