Patient's question:
I've been married for several years, and so far, we haven't had any children. I'm very anxious about it and don't know if it's my problem. I've asked my husband to get checked, but he refuses. I'm afraid my condition might worsen. Could you please tell me what are the main things to pay attention to for immune infertility?Doctor's answer:
The sperm and seminal fluid of males are considered specific antigens for females. Upon contact with blood, they can trigger autoimmune reactions in both men and women, leading to the production of additional antibodies that hinder the combination of sperm and eggs, resulting in infertility. The goal of treating immunological infertility is to reduce the titer of anti-sperm antibodies in the body, even eliminating them, so that sperm and eggs can combine normally, allowing for conception and childbirth.The main treatment method is isolation therapy: This involves using condoms to prevent and reduce contact between the female reproductive tract and sperm and its antigenic substances, thereby preventing the formation of new antibodies. Generally, this isolation is maintained for 6-12 months, during which the titer of anti-sperm antibodies in serum and cervical mucus is monitored. Once it returns to normal, conception may be possible.