Patient's question:
What are the causes of immunological infertility? Hello, I want to understand what immunological infertility is. I've been married for several years, but I still don't have any children. I'm very anxious myself, not knowing if it's my problem. I asked my husband to get checked, but he refuses. I'm afraid my condition will get worse.Doctor's answer:
The main reasons for immunological infertility are as follows:1. The Fc segment of antisperm antibodies binds to cervical mucus glycoproteins, affecting sperm penetration through the cervical mucus during the ovulation period, leading to female infertility.
Why is immunological infertility caused? Antisperm antibodies produced at the head of sperm impair sperm motility, resulting in female infertility.
The regulatory effect of antisperm antibodies reduces the phagocytic activity of sperm in the reproductive tract.
Cytotoxic antibodies, in the presence of complement, damage the sperm cell membrane, causing sperm to be on the verge of death. Antisperm antibodies targeting the tail inhibit sperm movement, leading to immunological infertility again.
Antisperm antibodies at the head of sperm can block the binding of sperm to the zona pellucida and oolemma, preventing fertilization, ultimately resulting in immunological infertility.