Patient's question:
I have been married for many years, and my husband and I have been actively trying to conceive, but we have never received any good news. We are very anxious. Could you please tell me: What are the reasons for immunological infertility?Doctor's answer:
The main reasons for immunological infertility are as follows:1. The Fc segment of antisperm antibodies binds to cervical mucus glycoproteins, affecting sperm penetration through the cervical mucus during the ovulation period, leading to female infertility.
2. Why is immunological infertility a cause? Antisperm antibodies produced against the sperm head impair sperm motility, resulting in female infertility.
3. The regulatory effect of antisperm antibodies reduces the phagocytic activity of sperm in the reproductive tract.
4. Cytotoxic antibodies, in the presence of complement, damage the sperm cell membrane, causing sperm to be on the verge of death. Antisperm antibodies targeting the sperm tail inhibit sperm movement, thereby leading to immunological infertility again.
5. Antisperm antibodies targeting the sperm head can block the binding of sperm to the zona pellucida and oocyte membrane, preventing fertilization, ultimately resulting in immunological infertility.