Patient's question:
I met my husband when I was in university, and we never took any contraceptive measures while dating. However, I have never been pregnant. Now that we are preparing to get married, my family elders keep urging me, which is really annoying. Please ask: How can I identify immune infertility, and what methods are reliable?Doctor's answer:
Immune infertility refers to infertility caused by immune factors. Immune infertility accounts for 10-30% of infertility cases, including various types such as antisperm antibodies, anti-endometrial antibodies, anti-ovum antibodies, and other immune-related infertility. Clinically, the most common form of immune infertility is caused by the production of antisperm antibodies. Due to reproductive tract inflammation in women, local secretion increases, allowing autoimmune cells to enter the reproductive tract. Simultaneously, changes in the reproductive tract mucosa reduce the processing of sperm antigens. Additionally, bacterial and viral infection factors may act as natural adjuvants, decreasing the body's autoimmune response to sperm antigens. As a result, antisperm antibodies reappear in the local reproductive tract and bloodstream, affecting sperm vitality and hindering fertilization, leading to infertility.