Patient's question:
What serious harm does immune infertility bring to patients? My daughter doesn't have much sexual activity, and I'm also quite attentive to her hygiene, but recently the girl always feels itchy outside her vulva, and her studies have been affected. She is very distressed.Doctor's answer:
1. Antisperm antibodies can prevent sperm from penetrating cervical mucus, causing sperm to clump together and obstruct sperm movement. Antisperm antibodies also exhibit cytotoxic reactions, leading to sperm death or interference with sperm motility. Additionally, they may interfere with sperm metabolism and the function of sperm condensin proteins.2. Interference with sperm enzyme activity and the aggregation of the zona pellucida and corona radiata include:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the aggregation of the corona radiata (egg cumulus). Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm aggregation.
The recurrence of immunological infertility severely impacts women's health, and patients should pay attention to maintaining clean external genital hygiene and avoiding sexual activity in daily life.