Patient's question:
What causes immunological infertility? I've been married for several years, but still haven't had any children. I'm very anxious and don't know if it's my problem. I asked my husband to get checked, but he refuses. I'm afraid my condition will worsen.Doctor's answer:
The main reasons leading to immunological infertility are as follows:1. The Fc segment of antisperm antibodies binds to cervical mucus glycoproteins, affecting sperm penetration through the cervical mucus during the ovulation period, resulting in female infertility.
Why is immunological infertility caused? Antisperm antibodies generated at the head of sperm impair sperm motility, leading to female infertility.
The regulatory effect of antisperm antibodies reduces the phagocytic activity of sperm in the reproductive tract.
Cytotoxic antibodies, in the presence of complement, cause damage to the sperm cell membrane, leading to sperm death. Antisperm antibodies targeting the tail inhibit sperm motility, thereby causing immunological infertility again.
Antisperm antibodies at the head of sperm can block the binding of sperm to the zona pellucida and oolemma, preventing fertilization, ultimately resulting in immunological infertility.