Patient's question:
I have been married for 14 years and have never used contraception during this time, but I haven't been able to get pregnant. Is it possible that I am infertile? Please ask: Do patients with immunological infertility need to pay attention to their diet?Doctor's answer:
The hazards of immunological infertility include the following points:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or impairing sperm motility. Additionally, they may also affect sperm metabolism and the function of sperm condensin proteins.
2. Impairing the movement of sperm enzymes, suppressing the aggregation function of the zona pellucida and corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the aggregation of the corona radiata (egg coat). Sperm antibodies primarily inhibit the activity of hyaluronidase, thereby affecting sperm aggregation.