Patient's question:
Married for many years, my husband and I have been actively trying to conceive, but there has been no good news so far. We are very anxious. How can immune infertility be treated to be cured?Doctor's answer:
Immunological infertility refers to infertility caused by immunological factors. Immunological infertility accounts for approximately 10-30% of infertility cases, including various types such as antisperm antibodies, anti-endometrial antibodies, anti-ovum antibodies, and other immunological infertility. Clinically, the most common form is immunological infertility caused by the production of antisperm antibodies. Due to reproductive tract inflammation in women, local secretion increases, allowing autoimmune-related cells to enter the reproductive tract. Simultaneously, changes in the reproductive tract mucosa enhance the processing of sperm antigens. Additionally, bacterial, viral, and other infectious agents may act as natural adjuvants, increasing the body's autoimmune response to sperm antigens. As a result, antisperm antibodies reappear in the local reproductive tract and bloodstream, interfering with sperm vitality and hindering fertilization, leading to infertility.