Patient's question:
I have been married for many years, and my husband and I have been actively trying to conceive, but we have never received any good news. We are very anxious. Could you please tell me what are the hazards caused by immunological infertility?Doctor's answer:
Hello, the harms of immunological infertility are as follows:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm motility. Sperm agglutinating antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm motility. Additionally, they may also interfere with sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the concentration effect of the zona pellucida and corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the concentration of the corona radiata (egg coat). Sperm antibodies primarily inhibit the activity of hyaluronidase, thereby affecting sperm concentration.