Patient's question:
I am 30 years old this year. Two years ago, I had a miscarriage naturally, and then I haven't been able to get pregnant. I went to check the reason, and it was found to be immunological infertility. Could you please tell me what are the harms of immunological infertility?Doctor's answer:
The hazards of immunological infertility include the following points:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm motility. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm movement. Additionally, they may disrupt sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the aggregation function of the zona pellucida and the corona radiata, including:
① Acrosin: Promotes sperm penetration through the zona pellucida and enhances fertilization;
② Hyaluronidase: Enables the corona radiata (egg coat) to aggregate. Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm aggregation.