Patient's question:
After one year of marriage, the couple had always wanted a child but had not been successful. After a thorough examination at the hospital, they discovered they had immunological infertility. I want to know what are the characteristics of immunological infertility?Doctor's answer:
The hazards of immunological infertility include the following points:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm motility. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm motility. Additionally, they may disrupt sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the concentration of the zona pellucida and the corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the concentration of the corona radiata (egg coat). Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm concentration.