Patient's question:
After getting married, I have been working hard to have a child, but I haven't been able to fulfill my wish. After checking at the hospital, it was found that it is immune infertility. Please ask: will the harm of immune infertility become more serious?Doctor's answer:
Hello, the harms of immunological infertility are as follows:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or affecting sperm motility. Additionally, they may also impact sperm metabolism and the function of sperm condensin proteins.
2. Affecting the movement of sperm enzymes, inhibiting the aggregation function of the zona pellucida and the corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Enables the corona radiata (egg coat) to aggregate. Sperm antibodies primarily inhibit the activity of hyaluronidase, thereby affecting sperm aggregation.