How is immunological infertility usually caused?

Patient's question:

I met my husband when I was in university, and we never took any contraceptive measures while dating. However, I have never been pregnant. Now that we are preparing to get married, my family elders keep urging me, which is really annoying. Please ask: How is immunological infertility usually caused?

Doctor's answer:

Immunological infertility is a common condition affecting many men and women today. The male testes possess a blood-testis barrier, and when this barrier is damaged, sperm leakage can lead to the production of antisperm antibodies. The formation of antisperm antibodies in women differs from that in men. Although sperm are foreign to women, they possess immunosuppressive effects on lymphocytes, which can inhibit the autoimmune response of the female body to sperm. However, if inflammation or injury occurs again, it can still trigger antibody production.
Hello, the causes of immunological infertility vary, and the symptoms exhibited by patients also differ. Blind treatment will only worsen the condition.

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