Patient's question:
I have been married for many years, and my husband and I have been actively trying to conceive, but we have never received any good news. We are very anxious. Please ask: How should one choose a hospital for immunological infertility?Doctor's answer:
Hello, the harms of immunological infertility are as follows:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm movement. Additionally, they may also interfere with sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the concentration effect of the zona pellucida and the corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Enables the cumulus (corona radiata) to concentrate sperm. Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm concentration.
3. Interfering with embryonic growth and development.