Patient's question:
After getting married to my husband, I have always wanted to have a little baby as soon as possible, but there has been no good news so far. A few days ago, I went for a check-up and found out that I have infertility. I feel like the sky is falling. Please ask: what are the causes of immunological infertility?Doctor's answer:
The hazards of immunological infertility include the following points:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm motility. Additionally, they may disrupt sperm metabolism and the function of sperm condensin proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the concentration effect of the zona pellucida and the corona radiata, including:
① Acrosin: Promotes sperm penetration through the zona pellucida and enhances fertilization;
② Hyaluronidase: Enables the cumulus (corona radiata) to concentrate sperm. Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm concentration.
3. Interfering with embryonic growth and development.