What are the causes of amenorrhea?

Patient's question:

I'm so frustrated. Menstruation came at the age of thirteen, either it came and didn't go away, or it didn't come at all. Married for eight years and never got pregnant. Had thorough checks, including hysterosalpingography and fallopian tube catheterization, and now it hasn't come for three months. What are the causes of amenorrhea?

Doctor's answer:

The causes of pathological amenorrhea are due to congenital defects in the lower segment of the reproductive tract, such as hymen atresia or postnatal adhesions, which prevent menstruation from flowing out, resulting in hidden amenorrhea or pseudomenorrhea. Congenital absence or hypoplasia of the ovaries, ovarian damage or removal, ovarian tumors, and premature ovarian failure leading to ovarian amenorrhea. Pituitary damage, pituitary tumors, and primary hypogonadotropic hypogonadism, which cause pituitary amenorrhea. Mental and neurological factors include wasting diseases, sex chromosome abnormalities, anemia, obesity, perinatal functional malnutrition, drug suppression syndrome, galactorrhea amenorrhea syndrome, polycystic ovary syndrome, and hypothalamic amenorrhea caused by other endocrine gland disturbances.

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