Does immunological infertility have a significant impact?

Patient's question:

I haven't been able to conceive for about a year. Later, when I went to the hospital for a check-up, I found out that I have immunological infertility. Is immunological infertility a major issue?

Doctor's answer:

Suffering from immunological infertility can interfere with the development of embryos. If a woman experiences immunological infertility again, it will directly interfere with the binding of sperm to the zona pellucida, leading to the production of cytotoxic effects, ultimately hindering the implantation of the fertilized egg and causing infertility. It can also interfere with the menopause of the ovaries. After immunological infertility reoccurs, it will directly interfere with the menopause of a woman's ovaries and also directly affect the endocrine function of the ovaries. Therefore, it ultimately disrupts the hypothalamic-ovarian axis function, causing abnormalities, ultimately interfering with the growth and development of follicles and sperm motility.
After immunological infertility reoccurs, it can block the ability of sperm to penetrate cervical mucus. The reappearance of antisperm antibodies will also hinder sperm motility, making it easier to lead to the recurrence of asthenozoospermia.

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