Patient's question:
The first child I had four years ago was quite normal. But now, when preparing for a second child, I haven't been able to conceive for a long time and suspect it might be my problem. Please ask: What are the best ways to deal with immune infertility?Doctor's answer:
1. Autoimmunity: Semen or female hormones, eggs, and other reproductive fluids flow out of the reproductive tract and enter the surrounding tissues of the body, triggering autoimmune reactions. This leads to the production of additional antibodies in the body, thereby affecting sperm vitality or interfering with follicle maturation and menopause, resulting in female immune infertility.2. Alloimmune Response: This is primarily caused by antibodies produced in the female body, leading to sperm agglutination or loss of vitality. In terms of data, approximately 15%–18% of women have sperm antibodies.
3. Local Autoimmunity: Lymphoid cells that produce immunoglobulin G and A are present in the cervical mucosa and endometrium, causing the female cervix and reproductive tract to develop a local autoimmune response against sperm, leading to infertility.