Patient's question:
After getting married to my husband, I have always wanted to have a little baby as soon as possible, but there has been no good news so far. A few days ago, I went for a check-up and found out that I have infertility. I feel like the sky is falling. Please ask: what are the harms of immune infertility?Doctor's answer:
1. Blocking sperm from penetrating cervical mucus, antisperm antibodies can cause sperm to clump together, hindering sperm movement. Antisperm antibodies exhibit cytotoxic reactions, leading to sperm death or affecting sperm motility. Additionally, they may have some impact on sperm metabolism and the function of sperm condensin proteins.2. Affecting the movement of sperm enzymes, inhibiting the aggregation function of the zona pellucida and the corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the aggregation of the corona radiata. Sperm antibodies primarily inhibit the activity of hyaluronidase, thereby affecting sperm aggregation.
3. Affecting embryonic growth and development. There are many different causes of autoimmune infertility, such as infections and bilateral reproductive tract blockages.