Patient's question:
I met my husband when I was in college, and we never took any contraceptive measures while dating. However, I have never been pregnant. Now that we are preparing to get married, the elders in my family keep urging me, which is really annoying. Please ask: Is immunological infertility harmful to patients?Doctor's answer:
Hello, the harms of immunological infertility are as follows:1. Blocking sperm from penetrating cervical mucus, anti-sperm antibodies can cause sperm to clump together, hindering sperm movement. Sperm immobilizing antibodies exhibit cytotoxic reactions, leading to sperm death or interference with sperm movement. Additionally, they may disrupt sperm metabolism and the function of sperm condensing proteins.
2. Interfering with the movement of sperm enzymes, inhibiting the aggregation function of the zona pellucida and the corona radiata, including:
① Acrosin: Enhances sperm penetration through the zona pellucida and promotes fertilization;
② Hyaluronidase: Facilitates the aggregation of the corona radiata. Sperm antibodies primarily inhibit the activity of hyaluronidase, affecting sperm aggregation.
3. Interfering with embryonic growth and development.