Patient's question:
Please help the doctor answer how to treat endometrial hyperplasia. I hope the expert can give a detailed answer. Thank you.Doctor's answer:
(1) Ovulation-inducing drugs: Ovulation-inducing drugs include clomiphene and human chorionic gonadotropin (hCG). They are generally used for patients with mild atypical hyperplasia of the endometrium. The dosage of clomiphene is 50–100 mg, once daily, taken on days 5–9 of the cycle. The medication period may be extended by 2–3 days if necessary.(2) Progestin drugs: Progestin drugs can inhibit estrogen-induced endometrial hyperplasia. Their mechanism of action:
① By inhibiting the secretion of hypothalamic and pituitary gonadotropins, they raise serum E2 levels to levels equivalent to the early follicular phase.
② By increasing the estrogen nuclear receptor levels in the endometrium.
③ By inhibiting the synthesis of DNA in the endometrium.