Patient's question:
My brother-in-law is 38 years old this year. I would like to ask the doctor what is the mechanism of bleeding in DIC patients?Doctor's answer:
The mechanism of skin peeling in DIC patients includes the following points:1. Consumption of coagulation substances. During the recurrence and progression of DIC, a large amount of coagulation factors and platelets are consumed.
2. Activation of the fibrinolytic system. In the process of DIC, the secondary fibrinolytic system is activated, leading to an increase in the formation of plasmin. Plasmin not only degrades fibrinogen but also hydrolyzes coagulation factors V, VIII, and prothrombin, further increasing these coagulation factors.
3. Massive production of fibrinogen degradation products. Fibrinogen degradation products have a strong anticoagulant effect, which leads to skin peeling.